Pomphlyx Blisters and CD11a

Finally found out what's up with those clear blisters on hands and feet. The condition is called Pomphlyx. It's a type of dermatitis, specifically eczema, that occurs during certain parts of the season contingent on allergies per person. It is also dependent on age and hormone levels. Apparently, the human antibody CD11a becomes highly activated following a sustained allergic event. Once fully expressed enzymes enable the corpuscles to release "toxins" to the epidermis, causing blisters. Because they are pressing against nerves the underlying skin becomes very itchy. Pretty freaky when you think about it. Anyway, the response is normal for many people in-between allergy seasons.

The entire condition is very analogous to prepubescence and pimples/acne. Pubescence sets markers, so to speak, in the human immune system. For example, if allergies have not conditioned a response in the body before puberty the body will most likely never develop a quick, reliable response to repress an allergic reaction. If you had zits when you were a kid, they will show up again in another form when you get older. It has to do with telomers and gene expression, as you get older your body just isn't going to produce as much of what it needs (mostly enzymes, specifically hormones) and the body "falls apart" so to speak.